Preheat oven to 425°F.
To a large mixing bowl, add the buttermilk, cornstarch, flour, chili powder, garlic powder, paprika, salt, and black pepper. Whisk together until you have a thick batter consistency.
Add the cauliflower florets and mix until all are coated evenly.
Then add the panko breadcrumbs and mix again.
Line a baking sheet with parchment paper and add the battered cauliflower so that they're not touching.
Pop in the oven to bake for 20 minutes.
Remove from the oven. Flip over each floret, spray with oil, and then bake for an additional 10 to 15 minutes until golden and crispy all around.
Once golden and crispy, take it out of the oven. Add to a bowl and add as little or as much buffalo sauce as you'd like and toss it.
Transfer back to the tray and bake for an additional 10 to 15 minutes.
Remove from the oven, top it off with chopped chives, and enjoy with some ranch or blue cheese dressing.